In-vivo, Phloretin CF provides a high level of environmental protection against UV-induced oxidative damage when exposed to solar-simulated light.
97% sunburn cell reduction. Protects against UVA/UVB - skin protected with Phloretin CF shows significantly lower levels of p53. p53 is an essential protective protein in skin, it's levels increase when skin is damaged. (Pinnell, S. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin - JCD - 2008).
Protects against ozone pollution - 47% reduction in NFkB activation. NFkB pathway is a marker of skin sensitisation in response to ozone pollution exposure (Valacchi, G. Protective Effects of Topical Vitamin C Compound Mixtures Against Ozone-Induced Damage in Human Skin - Journal of Investigative Dermatology - 2017).
After 24 weeks, 24% reduction in fine lines, 16% improvement in skin texture, 19% reduction of dullness and discolouration.
Proven to be safe when used post CO2 -78˚C cryotherapy treatment. Phloretin CF delivers a statistically-significant improvement in skin smoothness and general appearance at 1 week post-treatment compared to a lesion not treated with Phloretin CF. (Protocol: a 6-week clinical study, 44 subjects aged 35-65, Fitzpatrick I-III with two similar solar lentigines or actinic keratosis on face or hand. After one treatment with CryoCorrect PrecisionTM device, subjects applied Phloretin CF to one of the two lesions once daily for 6 weeks).